Podcasts - For your listening pleasure

Dr_SLO · Apr 2, 2020

This thread will be used to post informative podcasts about the SARS-CoV-2 outbreak and COVID. These are aimed at listeners who would like fact based information and discussion about the new coronavirus that is causing the current global pandemic.

The first few posts will be ones that I have already posted in the 'Corona Virus are you ready?' thread in the Kitchen Sink. This is highly recommended listening to help sort out the wheat from the chaff from the usual media outlets of your choice.

Dr_SLO · Apr 4, 2020

This Week in Virology (TWiV) - 591

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10540144#post10540144

Here is this week's episode of the virology podcast TWiV which is SARS-CoV-2/COVID19 centric…

http://www.microbe.tv/twiv/twiv-591/

Earlier in this thread I had stated that asymptomatic spread had not been proven with the data at that time. However, Raplh Baric, a coronavirus expert, suggests that this could be the case, I presume based on additional evidence.

Most of the topics in this week's podcast have been discussed in this thread. For those who are interested in why the CDC failed in supplying test kits you can jump to 1:25:23 where a listener with information has written in and provides the details.

Dr_SLO · Apr 4, 2020

TWiV - 592

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10543289#post10543289

There have been a number of questions raised and discussed in the last 24 hours...

The latest podcast from This Week in Virology (TWiV) http://www.microbe.tv/twiv/twiv-592/ discusses many of them in further detail. This really is a great resource to sort the wheat from the chaff supplied by the media at large.

Links for this episode

Scary modeling (Imperial College London) 3:47 - https://www.imperial.ac.uk/media/im...-College-COVID19-NPI-modelling-16-03-2020.pdf
Avigan vs SARS-CoV-2 (NHK) 9:57 - https://www3.nhk.or.jp/nhkworld/en/news/20200317_48/
SARS-CoV-2 mRNA vaccine (Clinical Trials) 14:52 - https://clinicaltrials.gov/ct2/show/NCT04283461?cond=mRNA-1273&draw=2&rank=1
SARS-CoV-2 stability (NEJM) 21:23 - https://www.nejm.org/doi/full/10.1056/NEJMc2004973?query=featured_home
Pediatric COVID-19 (one, two) 21:38 - https://www.nejm.org/doi/full/10.1056/NEJMc2003717?query=featured_home
SARS-CoV-2 asymptomatic infection (one, two) 24:38 - https://www.nejm.org/doi/full/10.1056/NEJMc2003100?query=featured_home and https://science.sciencemag.org/content/early/2020/03/13/science.abb3221
CDC data on SARS-CoV-2 CFR (MMWR) 26:20 - https://www.cdc.gov/mmwr/volumes/69/wr/mm6912e2.htm?s_cid=mm6912e2_x
Hydroxycholorquine trial for COVID-19 (Mediterranee-infection) 11:50 - https://www.mediterranee-infection....2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf
Macaque SARS-CoV-2 immunity (bioRxiv) 35:12 - https://www.biorxiv.org/content/10.1101/2020.03.13.990226v1
Image by Michele Banks - https://www.artologica.net/
Letters read on TWiV 592 38:17 - http://www.microbe.tv/twiv/twiv-592-letters/
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 4, 2020

TWiV - 593

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10545317#post10545317

The latest episode from This Week in Virology has been posted. Again coronavirus centric. The first 53 minutes has fascinating insights from a clinician, Daniel Griffin, currently serving on the front line in NYC. The healthcare professionals will find the information very useful so highly recommended listening for you folk. It also explains why TP might not be a bad thing to have, seriously...

http://www.microbe.tv/twiv/twiv-593/

Links for this episode

Pregnancy and COVID-19 papers (1, 2, 3, 4, 5) 48:45 - https://www.ncbi.nlm.nih.gov/pubmed/32151335
https://www.ncbi.nlm.nih.gov/pubmed/32186894
https://www.ncbi.nlm.nih.gov/pubmed/?term=32105680
https://www.ncbi.nlm.nih.gov/pubmed/?term=32050635
https://www.ncbi.nlm.nih.gov/pubmed/?term=32134165
Second dog infected with SARS-CoV-2 (ProMedMail) 53:13 - https://promedmail.org/promed-post/?id=7112693
Italian site with infographic in English 1:16:25 - https://www.epicentro.iss.it/coronavirus/sars-cov-2-sorveglianza-dati
Image by Michele Banks - https://www.artologica.net/
Letters read on TWiV 593 1:13:35, 1:17:01 - http://www.microbe.tv/twiv/twiv-593-letters/
Timestamps by Jolene. Thanks! - http://www.twitter.com/jrrmicro

Dr_SLO · Apr 4, 2020

TWiV -594 plus Mark Denison special

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10548425#post10548425

This Week in Virology has released two new coronavirus centric podcasts.

First up is a special with Mark Denison a pediatric infectious disease physician and coronavirologist. Fascinating insights and introduces a subtle way of thinking about virus infection a little differently. He also discusses his work on drugs against coronaviruses.

http://www.microbe.tv/twiv/twiv-special-denison/

Second up is a regular style podcast that answers a lot of question by listeners. It covers many topics that have been discussed in this thread plus some other concerns that have been raised including the potential of coronavirus transmission via the mail.

http://www.microbe.tv/twiv/twiv-594/

Links for this episode

Coronavirus test kit 17:46 - https://www.alphabiolabs.co.uk/workplace-testing-services/coronavirus-testing-kit/
Rapid SARS-CoV-2 serological assay (medRxiv) 19:27 - https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v1.full.pdf
Is Dr. Fauci in trouble? (NY Times) 20:17 - https://www.nytimes.com/2020/03/23/us/politics/coronavirus-trump-fauci.html
FDA approves emergency use of convalescent serum (FDA) 21:46 - https://www.fda.gov/vaccines-blood-...l-covid-19-convalescent-plasma-emergency-inds
Image by Michele Banks - https://www.artologica.net/
Letters read on TWiV 594 14:09, 21:22, 28:43 - http://www.microbe.tv/twiv/twiv-594-letters/
Timestamps by Jolene. Thanks! - http://www.twitter.com/jrrmicro

Dr_SLO · Apr 4, 2020

TWiV Special - Ian Lipkin

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10549689#post10549689

The This Week in Virology podcast has released a special with Ian Lipkin.

http://www.microbe.tv/twiv/twiv-special-lipkin/

Dr. Lipkin is the John Snow Professor of Epidemiology, Professor of Neurology and Pathology and Cell Biology, and Director at the Center for Infection and Immunity internationally at Columbia. He is recognized as an authority on the use of molecular methods for pathogen discovery.

Ian is currently in the midst of suffering from COVID-19 and he talks about the issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.

Dr_SLO · Apr 4, 2020

TWiV - 595

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10550235#post10550235

This Week in Virology have posted their weekly episode...

http://www.microbe.tv/twiv/twiv-595/

The first 35 minutes are, in my opinion, critical listening for those in the medical field and others who would like to know more about patient outcomes. Dr. Daniel Griffin took time on his break from working in a NYC hospital to talk about what's currently going on at the current epicenter of the SARS-CoV-2 outbreak. Some really useful and fascinating information.

Links for this episode

Tocilizumab (Wiki) 17:40 - https://en.wikipedia.org/wiki/Tocilizumab
Nares swab for SARS-CoV-2 (Star Trib) 10:01 - https://www.startribune.com/unitedhealth-group-pushes-self-collected-covid-19-test/569111292/
US SARS-CoV-2 epidemic curve (CDC) 37:05 - https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html
Cleaning and disinfecting (CDC) 43:56 - https://urldefense.proofpoint.com/v...7EcxfiHy_RKZ373EfofBKj7l0KmBSoZxp0yULd-xu0&e=
Cleaning fruits and vegetables (FDA) 44:32 - https://www.fda.gov/consumers/consumer-updates/7-tips-cleaning-fruits-vegetables
Coronavirus food safety (FDA) 45:29 - https://www.usda.gov/coronavirus
Vaccine development for SARS-CoV-2 (pdf) 49:31 - https://urldefense.proofpoint.com/v...x8UUlXBc7Ex_KujgTdRmQE9P_qBfOIonIKxfY3Jx4c&e=
Image by Lachie 1:30:25
Letters read on TWiV 595 51:42 - http://www.microbe.tv/twiv/twiv-595-letters/
Timestamps by Jolene. Thanks! - http://www.twitter.com/jrrmicro

Dr_SLO · Apr 4, 2020

Immune 29: Immunology of COVID-19

Originally posted here...
https://www.bayarearidersforum.com/forums/showthread.php?p=10551717#post10551717

The 'This week in' series has another coronavirus centric show from their Immune podcast. I'll say this up front, it's a podcast that focusses on immunology, which is quite a complex topic, mostly because it has a language of its own. However, there is some very useful information about how SARS-CoV-2 is causing disease and why COVID is fatal for some...

https://www.microbe.tv/immune/immune-29/

Links for this episode

ACE2 in oral mucosa (I J Oral Sci) - https://www.nature.com/ijos
IL6 predictor of COVID-19 death (Int Care Med) - https://link.springer.com/article/10.1007/s00134-020-05991-x
Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) - https://www.biorxiv.org/content/10.1101/2020.03.13.990226v1
Antibody to SARS-CoV wanes (J Immunol) - https://www.jimmunol.org/content/jimmunol/early/2011/05/16/jimmunol.0903490.full.pdf
Image credit - https://www.artologica.net/
Time stamps by Jolene. Thanks! - http://www.twitter.com/jrrmicro

Dr_SLO · Apr 4, 2020

TWiV - 596

Another great episode from the TWiV podcast...
https://www.microbe.tv/twiv/twiv-596/

This weeks covers a range of topics including the FDA's emergency approval of hydroxychloroquine and using plasma from recovered patients as a treatment for COVID.

Links for this episode

Emergency use of hydroxychloroquine (FDA) 16:01 - https://www.fda.gov/media/136534/download
Trial of hydroxycholorquine in COVID-19 patients (China, France) 18:33, 20:43 - https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v1;https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf
COVID-19 in critically ill patients, Seattle (NEJM) 22:42 - https://www.nejm.org/doi/full/10.1056/NEJMoa2004500?query=featured_home
Feasibility of convalescent plasma therapy for COVID-19 (medRxiv) 24:14 - https://www.medrxiv.org/content/10.1101/2020.03.16.20036145v1
Letters read on TWiV 596 29:00 - https://www.microbe.tv/twiv/twiv-596-letters/
Timestamps by Jolene. Thanks! - http://www.twitter.com/jrrmicro

Dr_SLO · Apr 5, 2020

TWiV - 597

A new TWiV podcast has been released; A lot of immunology and some COVID-19 with Jon Yewdell

There is a lot of immunology (the discipline that studies the body's response to infectious diseases) discussed in this episode, which increases in complexity as the conversation with Jon Yewdell progresses. The podcast touches on concepts of immunology in the context of viruses with some coronavirus overlap. Fascinating stuff!

Dr_SLO · Apr 5, 2020

TWiV 598: Who was that masked man?

The latest TWiV has been made available to day. Daniel Griffin provides more essential information for healthcare workers in the first half hour of this podcast and the TWiV crew continue to discuss questions from the listeners.

Links for this episode

Restricted dispensing of Plaquenil in NY state 22:00
Virology of COVID-19 patients (Nature) 31:37
Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv) 36:23
Cloth face masks for all of US (NY Times) 40:34
Masks and respiratory virus shedding (Nat Med) 41:30
50 million face masks to Japanese households (Kyodo News) 47:50
More than you want to know about face masks (Slate Star Codex) 47:58
Why is COVID-19 less severe in children? (virology blog) 51:05
Tracking SARS-CoV-2 in sewage (UM) 52:10
1918 flattening the curve (Nat Geo) 53:11
COVID near you 54:30
Pandemic stops polio eradication (Science) 55:37
SARS-CoV-2 vaccine patch in mice (U Pitt) 1:00:23
Letters read on TWiV 598 1:03:32
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 7, 2020

TWiEVO 53: Virus evolution by land and by sea and by CoV, part II

Here's another coronavirus centric podcast from the This Week in crowd. This Week in Evolution (TWiEVO) is one of my favourites as it brings together many disciplines that uncover the genetic basis for what we see in everyday creatures or plants. Episode 53 of TWiEVO discusses SARS-CoV-2 from an evolutionary viewpoint, giving great insights into why this new coronavirus is considered a single species and tracking its global spread.

Links for this episode

Clement Chow with COVID-19 (Salt Lake Trib) 11:30
Scientists exposed to coronavirus (Nature) 14:15
CoV by Britt Glaunsinger (YouTube) 25:50
Genetic epidemiology of novel coronavirus (nextstrain.org) 31:01, 42:21
Time stamps by Jolene. Thanks!

Dr_SLO · Apr 9, 2020

TWiV 599: Coronavirus update – we need a plan

The midweek coronavirus update from TWiV is available. The hosts discuss another potential anti SARS-CoV-2 compound, ivermectin, an anthelmintic that's typically used to treat for parasitic worms. They're also searching for an exit strategy plus a whole range of other useful discussions.

Links for this episode

Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) 2:39
Tiger at NY zoo positive for SARS-CoV-2 (NY Times) 28:30
IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) 36:00
Infection fatality rate for managing pandemic (virology blog) 40:39
Letters read on TWiV 599 32:36, 1:01:51
Image credit
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 12, 2020

TWiV 600: SARS-CoV-2 – enter the Coronials

In TWiV's 600th episode Daniel Griffin is back from a NYC hospital parking lot to provide his latest insights of treating COVID; fascinating stuff. The rest of the team discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Links for this episode

382 nt deletion in genome of SARS-CoV-2 (bioRxiv) 45:23
Recombination and mutation leading to SARS-CoV-2 (bioRxiv) 49:09
Letters read on TWiV 600 20:39, 31:47, 41:34, 42:48, 54:15
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 14, 2020

TWiV 601: Das coronavirus with Christian Drosten

Another special episode from TWiV where coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

There's more great information in this latest podcast. Especially how Germany have handled their outbreak so far but how to tackle releasing lockdown measures and what's needed to do so.

Links for this episode

Das Coronavirus podcast 1:00
Identification of SARS-CoV in Germany (NEJM) 3:13
29 nt deletion in genome of SARS-CoV (Sci Rep) 34:20
382 nt deletion in genome of SARS-CoV-2 (bioRxiv) 38:00
Virological assessment of COVID-19 patients (Nature) 26:29
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 16, 2020

TWiV 602: Coronavirus Immunology with Stanley Perlman

In TWiV 602 Stanley Perlman, pediatrician and coronavirus expert, discusses immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, plus prospects for a vaccine. This is a great reference point for what to expect as vaccines start to be developed for SARS-CoV-2; it might be a long journey.

Links for this episode

Perlman Laboratory 1:39
An Iowa Caucus of Viruses (TWiV 538) 2:00
Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) 28:07
T cell responses to respiratory CoV (Immunol Res) 19:13
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 20, 2020

TWiV 603: Cloudy with a chance of coronavirus

More great information in episode 603 of TWiV from Daniel Griffin at the epicenter of the US outbreak in NYC. He provides some eye-opening information about new symptoms but also how the treatment of COVID is being approached. Also, Vincent rants about the proposal that SARS-CoV-2 was engineered in a lab. They also cover the seroprevalence study from Stanford that the media have picked up on. My personal critique of that paper can be found elsewhere.

Links for this episode

CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) 51:47
SARS-CoV-2 screening before delivery (NEJM) 54:49
SARS-CoV-2 seroprevalence in Santa Clara (medRxiv) 1:01:36
SARS-CoV-2 seroprevalence in homeless shelter (NEPR) 57:38
Letters read on TWiV 603 1:08:38
Image credit[/ur;]
[*]Timestamps by [url=http://www.twitter.com/jrrmicro]Jolene. Thanks!

Dr_SLO · Apr 22, 2020

Immune 30: Immunology of COVID-19, part two

More excellent discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines in Immune episode 30.

Links for this episode

IL6 as COVID-19 marker for severity (Med Mal Infect) 29:04
How does COVID-19 kill? (Nature) 29:59
SARS-CoV-2 protective immunity[url] in macaques (bioRxiv) 56:05
[*]SARS [url=https://www.jimmunol.org/content/jimmunol/early/2011/05/16/jimmunol.0903490.full.pdf]antibody titers wane (J Immunol) 43:04
Vaccine roundup (Lab Equip) 46:21
Lung IgG in SARS injury (JCI Insight) 55:31
Image credit
Time stamps by Jolene. Thanks!

Dr_SLO · Apr 23, 2020

TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection

Here's a real curiosity, could the oral polio vaccine help to prevent the spread of SARS-CoV-2? In TWiV 604 Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Links for this episode

Nonpathogenic enteroviruses to prevent human disease (pdf) 6:13
OPV for COVID-19 (pdf) 17:56
Enteroviruses to prevent human infections (pdf) 7:08
Image credit.
Timestamps by Jolene. Thanks!

Dr_SLO · Apr 23, 2020

TWiV 605: READDI for the next pandemic

Remdesivir seems to be having some success in the treatment of COVID-19. In TWiV 605 Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, that was partly involved in the development of remdesivir and is starting to make drugs now for the next pandemic virus.

Links for this episode

READDI.org
CEPI
DNDi
Timestamps by Jolene. Thanks!

Podcasts - For your listening pleasure

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