Maybe a tiny bit. The rolling resistance of the tire is mostly caused by its construction and the materials used. The knob size and shape have a smaller effect on RR, in part because fast MTB tires already don’t have big chunky knobs. The tire could get more aerodynamic as it wears. But you “can’t see aero” so there’s no rule of thumb.
Tire pressure is very dependent on rider weight and tire size. You can try this calculator. I generally run a little lower than it suggests, but some ppl run a little higher.
axs.sram.com