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Podcasts - For your listening pleasure

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TWiV 669: All the wrong COVID-19 moves

In TWiV 669 Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions.

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TWiV 670: Coronavirus vaccine preparedness with Kizzmekia Corbett

In episode 670 Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus.

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TWiV 671: Prizes, polio, and a pandemic puzzle

In TWiV 671 Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.

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TWiV 672: Black in Microbiology with Ari Kozik and Kishana Taylor

In episode 672, Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron’s SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions.

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TWiV 673: Wake up and smell the pandemic

In TWiV 673 Daniel Griffin provides a clinical report on COVID-19, the Great Barrington Declaration is debunked, and discussions about smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells.

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TWiV 674: In the company of coronaviruses with Lisa Gralinski

In episode 674 Lisa Gralinski joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions.

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TWiV 675: Forget what you’ve herd about immunity

In TWiV 675 Daniel Griffin provides a clinical report on COVID-19, then the team discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus.

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TWiV 676: Tragic gene flow from Neanderthals

In episode 676 the TWiV crew explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.

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TWiV 677: Does antibody really know what time it is?

In TWiV 677 Daniel Griffin provides a clinical report on COVID-19, then the TWiV crew discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more.

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TWiV 678: Fishing for viruses with Nels Elde

In Episode 678 Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.

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TWiV 679: Mink, mutation, and myocytes

In TWiV 679 Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.

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TWiV 680: Long-term COVID and ME/CFS

In Episode 680 Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.

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TWiV 681: Crowley, coats, and cross-reactive antibodies

In TWiV 681 Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.

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TWiV 682: Kate Rubins from the International Space Station

Fancy a break from COVID? Then check out Episode 682. From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.

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TWiV 683: Two COVID-19 mRNA vaccines

On TWiV 683, discussions about mRNA vaccines from Moderna and Pfizer that show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.

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TWiV 684: Persistence of SARS-CoV-2 immune memory

In TWiV 684 Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.

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TWiV 685: Pandemicky

In Episode 685, the TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.

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TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin

In TWiV 686 Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.

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TWiV 687: Peter Hotez sticks to the vax

In TWiV 687 Peter Hotez discusses the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.

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TWiV 688: We put COVID-19 papers through a sieve

In Episode 688, the UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication.

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