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Podcasts - For your listening pleasure

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TWiV 710: COVID-19 clinical update #46 with Dr. Daniel Griffin

TWiV 710 contains COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients.

Links for this episode
  • Evaluation of Abbott BinaxNOW (MMWR) 17:00
  • Lilly mAb in nursing homes (WSJ) 18:16
  • Vitamin D and COVID-19 severity (Mayo Clin Proc) 19:56
  • Anticoagulation, aspirin, in-hospital mortality in COVID-19 (medRxiv) 21:19
  • Long COVID symptoms in outpatients (Ann Int Med) 27:07
  • {url=https://www.microbe.tv/twiv/twiv-710-letters/]Letters read[/url] on TWiV 710 27:48
  • Timestamps by Jolene. Thanks!
 
TWiV 711: The New Heal

In Episode 711, the TWiVers review Biden’s national strategy for COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.

Links for this episode
  • Biden’s COVID-19 strategy (pdf) 10:30
  • CDC evaluation of BinaxNOW antigen test (MMWR) 52:09
  • FDA instructions for BinaxNOW test (pdf) 52:28
  • Adam Neely on Sea Shanties (YouTube) 1:05:29
  • Letters read on TWiV 711 1:06:55
  • Timestamps by Jolene. Thanks!
 
TWiV 712: Deutscher Virus Wahnsinn

In Episode 712, Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.

Links for this episode
 
TWiV 713: COVID-19 clinical update #47 with Dr. Daniel Griffin

In COVID-19 clinical update #47 (TWiV 713), Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease.

Links for this episode
 
TWiV 714: The shape of spike with Jason McLellan

In Episode 714, Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.

Links for this episode
 
TWiV 715: Fauci ouchy

In Episode 715, TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.

Links for this episode
 
TWiV 716: COVID-19 clinical update #48 with Dr. Daniel Griffin

In TWiV's COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.

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TWiV 717: Paul and Theodora, pandemic explorers

In TWiV 717, Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.

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TWiV 718: Recombining vaccine schedules

In Episode 218, TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.

Links for this episode
 
TWiV 719: COVID-19 clinical update #49 with Dr. Daniel Griffin

In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.

Links for this episode
 
TWiV 720: With vaccines, Offit is on it

In Episode 720, Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.

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TWiV 721: COVID-19 clinical update #50 with Dr. Daniel Griffin

In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.

Links for this episode
 
TWiV 722: More coronaviruses in the pipeline

In TWiV 722 the entire team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.

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TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin

In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.

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TWiV 725: Eva Harris and Janet Smith clip flavivirus wings

Episode 725 is a little off the COVID topic with Eva Harris and Janet Smith joining TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.

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TWiV 726: Molecular animator Janet Iwasa

In Episode 726, Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.

Links for this episode
  • The Animation Lab 45:04, 1:16:38
  • SARS-CoV-2 animation 51:46
  • Documents for J&J COVID-19 vaccine review (FDA) 1:17:51
    • Phase III data (pdf) 1:18:39
    • Slide presentation of data (pdf) 1:22:08
    • Addendum (pdf) 1:29:41
    • Summary of v-Safe data (pdf) 1:34;50
  • Timestamps by Jolene. Thanks!
 
TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin

In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.

Links for this episode
 
TWiV 728: Cover your nose and mouse

In Episode 728, TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.

Links for this episode
 
TWiV 729: A floret of spikes with Matt Frieman

In TWiV 729, Matt Frieman returns to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.

Links for this episode
 
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